Water Treatment for Pharmaceuticals and Biotech

In pharmaceutical and biotech manufacturing, water purity isn’t just important—it’s regulated. From ingredient formulation and equipment sterilization to cleanroom operation and final product preparation, ultra-pure water is essential at every stage. Any contamination can compromise product safety, quality, and compliance. At Culligan Texas, we design high-performance water treatment systems tailored to the stringent requirements of pharmaceutical and biotech facilities.

Whether you need purified water for USP-grade applications, systems that support clean-in-place (CIP) operations, or solutions for water reuse and environmental compliance, our technologies are built to help you meet critical quality standards while improving operational efficiency.

For over 74 years, we’ve delivered high-performance water treatment solutions designed to meet the strict regulatory and purity requirements of the pharmaceutical and biotech industry, such as:

  • Purified Water & WFI Production – Generate water that meets USP standards for use in drug formulation, injectables, and other regulated applications.
  • Clean-In-Place (CIP) System Support – Provide high-purity water for automated cleaning processes to ensure residue-free sterilization and reduce contamination risk.
  • High-Efficiency Filtration & Pretreatment – Remove particulates, organics, and chlorine that can interfere with sensitive downstream processes and degrade water quality.
  • Wastewater Treatment & pH Control – Safely neutralize and treat pharmaceutical waste streams to meet environmental and compliance standards.
  • Cooling & Utility Water Conditioning – Prevent scale and microbial growth in HVAC and process cooling systems that support facility operations.
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Water Quality Targets & Treatment Insights for Pharmaceuticals and Biotech

  • Meets USP <1231> standards for Purified Water using EDI and RO systems, ensuring compliance with chemical and microbial specifications required in pharmaceutical production.
  • Conductivity control, per USP <645>, targets ≤1.3 µS/cm at 25 °C via online monitoring, enabling real‑time tracking of ionic purity in the water distribution system.
  • Total Organic Carbon (TOC) is monitored, with USP defining limits (e.g., ≤500 ppb) to prevent biofilm and endotoxin generation in high-purity water loops.
  • Water for Injection (WFI) requires RO or distillation, plus strict endotoxin control (<0.25 EU/mL) and low bacterial counts (<10 CFU/100 mL), ensuring suitability for parenteral-grade applications.

Why Choose Culligan Texas?

At Culligan Texas, we bring unmatched expertise to every project. Our team—from our office staff to our service technicians and sales consultants—has extensive experience in designing and implementing water treatment solutions tailored to the diverse needs of the pharmaceuticals and biotech industry.

With over 74+ years of combined industry experience, fair pricing, and a 90-day service guarantee, we are committed to providing exceptional products, reliable service, and ongoing support to ensure your water systems operate at peak performance.

Our Pharmaceuticals and Biotech Water Treatment Solutions

Culligan Texas delivers precision-engineered water treatment systems built to meet the strict purity, safety, and regulatory demands of pharmaceutical and biotech manufacturing.

Our solutions include:

  • Deionization (DI) – Produce water with minimal ionic contamination for use in formulation, equipment rinse, and sterile manufacturing environments.
  • Reverse Osmosis (RO) – Deliver high-purity feed water for DI systems, reducing total dissolved solids and organic impurities that can compromise product quality.
  • Filtration Systems – Apply multi-stage filtration (including carbon and sediment filters) to remove particles, chlorine, and organics from incoming water sources.
  • Ultraviolet (UV) Disinfection – Eliminate microbial contamination without chemicals—ideal for purified water loops and pharmaceutical-grade systems.
  • Dealkalization – Control alkalinity to reduce scaling in boilers and sterilization systems, supporting equipment performance and process consistency.

At Culligan Texas, we help pharmaceutical and biotech operations achieve consistent water quality, reduce contamination risk, and maintain full regulatory compliance. Whether you’re expanding production or optimizing existing systems, we’ll design a water treatment solution tailored to your facility’s critical requirements.